N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

Base Information

Chemical Name:N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide
CAS No.:1612842-19-9
Molecular Formula:C₁₉H₁₆ClFN₄O₄S
Molecular Weight:450.878
Hs Code.:

Synonyms:N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

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Chemical Property of N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

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Technology Process of N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

There total 4 articles about N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1612842-13-3
3-chloro-4-(2-fluoro-4-(2-(N-phenylsulfamoyl)acetamido)phenoxy)picolinamide

: 1612842-19-9
N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

Guidance literature:: With [bis(acetoxy)iodo]benzene; In water; ethyl acetate; acetonitrile; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.04.056

Reference yield:

: 62-53-3
aniline

: 1612842-19-9
N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium hydroxide / methanol; water / 3 h / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 2 h / 20 °C / Inert atmosphere

With dmap; [bis(acetoxy)iodo]benzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; acetonitrile; 4: |Hofmann Rearrangement;
DOI:10.1016/j.ejmech.2014.04.056

Reference yield:

: 7117-21-7
2‐(phenylsulfamoyl)acetatic acid

: 1612842-19-9
N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(N-phenylsulfamoyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 2 h / 20 °C / Inert atmosphere

With dmap; [bis(acetoxy)iodo]benzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; ethyl acetate; acetonitrile; 2: |Hofmann Rearrangement;
DOI:10.1016/j.ejmech.2014.04.056