{4-[(5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]phenoxy}acetic acid

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Chemical Name:{4-[(5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]phenoxy}acetic acid
CAS No.:423745-93-1
Molecular Formula:C₂₅H₂₁ClN₂O₆S
Molecular Weight:512.971
Hs Code.:
Mol file:423745-93-1.mol

Synonyms:2-(4-((5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidin-2-ylidene)methyl)phenoxy)acetic acid

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Chemical Property of {4-[(5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]phenoxy}acetic acid

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Technology Process of {4-[(5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]phenoxy}acetic acid

There total 4 articles about {4-[(5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]phenoxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

: 181058-43-5
ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

: 22042-71-3
(4-formylphenoxy)acetic acid

: 423745-93-1
2-(4-((5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidin-2-ylidene)methyl)phenoxy)acetic acid

Guidance literature:: With acetic acid; 3-amino propanoic acid; at 100 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.09.096

Reference yield:

: 141-97-9
ethyl acetoacetate

: 423745-93-1
2-(4-((5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidin-2-ylidene)methyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: cerium(III) chloride heptahydrate / ethanol / 5 h / Reflux

2: sodium acetate / acetic acid; acetic anhydride / 6 h / Reflux

3: 3-amino propanoic acid; acetic acid / 1 h / 100 °C

With cerium(III) chloride heptahydrate; sodium acetate; acetic acid; 3-amino propanoic acid; In ethanol; acetic anhydride; acetic acid; 1: |Biginelli Pyrimidone Synthesis / 3: |Aldol Condensation;
DOI:10.1016/j.ejmech.2014.09.096

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 423745-93-1
2-(4-((5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidin-2-ylidene)methyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: cerium(III) chloride heptahydrate / ethanol / 5 h / Reflux

2: sodium acetate / acetic acid; acetic anhydride / 6 h / Reflux

3: 3-amino propanoic acid; acetic acid / 1 h / 100 °C

With cerium(III) chloride heptahydrate; sodium acetate; acetic acid; 3-amino propanoic acid; In ethanol; acetic anhydride; acetic acid; 1: |Biginelli Pyrimidone Synthesis / 3: |Aldol Condensation;
DOI:10.1016/j.ejmech.2014.09.096