4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one

Base Information

• Chemical Name: 4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one
• CAS No.: 1018440-24-8
• Molecular Formula: C₂₁H₂₁N₃O₃
• Molecular Weight: 363.416
• Mol file: 1018440-24-8.mol

Synonyms:4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one

Chemical Property of 4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one

There total 1 articles about 4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(benzyloxy)-6'-fluoro-2H-1,3'-bipyridin-2-one (1018442-84-6) + (3R)-pyrrolidinol (40499-83-0,83220-72-8,100243-39-8,2799-21-5) → 4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one (1018440-24-8)

Guidance literature:

4-(benzyloxy)-6'-fluoro-2H-1,3'-bipyridin-2-one; (3R)-pyrrolidinol; In dimethyl sulfoxide; at 150 ℃; for 0.5h;

With sodium hydrogencarbonate; In water; dimethyl sulfoxide; at 20 ℃; Product distribution / selectivity;

Reference yield: 78.0%

4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one (1018440-24-8) + t-butyldimethylsiyl triflate (69739-34-0) → 4-(Benzyloxy)-6'-[(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one (1018443-22-5)

Guidance literature:

With 1H-imidazole; dmap; In acetonitrile; at 50 ℃; for 1h;

Reference yield: 42.0%

4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one (1018440-24-8) → 4-(Benzyloxy)-6'-(3-oxopyrrolidin-1-yl)-2H-1,3'-bipyridin-2-one

Guidance literature:

4-(benzyloxy)-6'-[(3R)-3-hydroxypyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1.08333h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

4-(benzyloxy)-6'-fluoro-2H-1,3'-bipyridin-2-one

(3R)-pyrrolidinol

Downstream raw materials:

4-(Benzyloxy)-6'-[(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-1-yl]-2H-1,3'-bipyridin-2-one