20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol

Base Information

Chemical Name:20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol
CAS No.:188976-72-9
Molecular Formula:C₅₄H₇₁NO₁₂Si
Molecular Weight:954.243
Hs Code.:

Synonyms:20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol

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Chemical Property of 20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol

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Technology Process of 20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol

There total 2 articles about 20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 189102-09-8
3β-[(tri-O'-benzoyl-α-L-rhamnopyranosyl)oxy]-21-nitro-5β-pregnane-14β,20(R)-diol

: 188976-72-9
20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol

Guidance literature:: With triethylamine; In dichloromethane; for 1.5h;
DOI:10.1021/jm960880l

Reference yield:

: 145345-70-6
14-hydroxy-3β-<(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy>-21-nor-5β,14β-pregnane-20-carboxaldehyde

: 188976-72-9
20(R)-(tert-butyldimethylsiloxy)-21-nitro-3β-[(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy]-5β-pregnane-14β-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / KF / propan-2-ol / 16 h

2: 51 percent / Et₃N / CH₂Cl₂ / 1.5 h

With potassium fluoride; triethylamine; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jm960880l