5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

Base Information

Chemical Name:5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine
CAS No.:1437778-70-5
Molecular Formula:C₂₅H₂₈ClFN₄O₂
Molecular Weight:470.974
Hs Code.:

Synonyms:5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

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Chemical Property of 5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

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Technology Process of 5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

There total 6 articles about 5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437778-70-5
5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

5.1: gold(III) chloride / dichloromethane; acetonitrile / 48 h / 20 °C

With gold(III) chloride; di-tert-butyl-diazodicarboxylate; sulfuric acid; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-N-ethynylacetamide

: 1437778-70-5
5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

Guidance literature:: With gold(III) chloride; In dichloromethane; acetonitrile; at 20 ℃; for 48h;

Reference yield:

: 91361-59-0
methyl 2-(2-fluoro-4-hydroxyphenyl)acetate

: 1437778-70-5
5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3-oxazol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

2.2: pH 4

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: gold(III) chloride / dichloromethane; acetonitrile / 48 h / 20 °C

With gold(III) chloride; di-tert-butyl-diazodicarboxylate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;