(6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:(6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester
CAS No.:144347-50-2
Molecular Formula:C₃₀H₃₆BrNO₈Si
Molecular Weight:646.607
Hs Code.:

(6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

Synonyms:(6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

Suppliers and Price of (6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

There total 10 articles about (6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3634-56-8
isopropyldimethylsilyl chloride

: 144347-50-2
(1S,2R,3S,6R)-6-(N-(benzyloxycarbonyl)-N-(o-bromopiperonyl)amino)-1,2-O-isopropylidene-3-((isopropyldimethylsilyl)oxy)cyclohex-4-ene-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / CH₂Cl₂ / 10 h

2: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h

With 1H-imidazole; n-butyllithium; In dichloromethane;

Reference yield:

: 138430-37-2
(1S,2R,3S,6R)-6-Benzyloxycarbonylamino-1,2-O-isopropylidenecyclohex-4-ene-1,2,3-triol

: 144347-50-2
(1S,2R,3S,6R)-6-(N-(benzyloxycarbonyl)-N-(o-bromopiperonyl)amino)-1,2-O-isopropylidene-3-((isopropyldimethylsilyl)oxy)cyclohex-4-ene-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / CH₂Cl₂ / 10 h

2: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h

With 1H-imidazole; n-butyllithium; In dichloromethane;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 144347-50-2
(6-Bromo-benzo[1,3]dioxole-5-carbonyl)-[(3aS,4S,7R,7aS)-7-(isopropyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Pseudomonas putida

2: DMP, p-TsOH

3: 74 percent / Bu₄NIO₄ / CH₂Cl₂

4: 91 percent / aluminum amalgam / tetrahydrofuran / 0 °C

5: 98 percent / Im / CH₂Cl₂

6: 1.) BuLi / 1.) THF, -78 deg C, 2.) THF

With n-butyllithium; aluminium amalgam; phthalic acid dimethyl ester; impramine; tetrabutylammonium periodite; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00050a079