(E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide

Base Information

• Chemical Name: (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide
• CAS No.: 82281-23-0
• Molecular Formula: C₂₂H₂₁NO₅S
• Molecular Weight: 411.478

Synonyms:(E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide

Chemical Property of (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide

There total 3 articles about (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzylamine (100-46-9) → (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide (82281-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄ / toluene / 1 h / 0 °C

2: N,N-diethylaniline / benzene / 1.) -78 deg C, 2 h, 2.) RT, 2 h

With magnesium sulfate; N,N-diethylaniline; In toluene; benzene;

DOI:10.1021/jo00140a008

Reference yield:

benzo[1,3]dioxol-5-yl-acetaldehyde (6543-34-6) → (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide (82281-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄ / toluene / 1 h / 0 °C

2: N,N-diethylaniline / benzene / 1.) -78 deg C, 2 h, 2.) RT, 2 h

With magnesium sulfate; N,N-diethylaniline; In toluene; benzene;

DOI:10.1021/jo00140a008

Reference yield:

[2-Benzo[1,3]dioxol-5-yl-eth-(Z)-ylidene]-benzyl-amine (620601-36-7) + 2-(2,5-Dihydro-1,1-dioxothienyl)acetyl chloride (73670-94-7) → (E)-N-benzyl-N-<<3,4-(methylenedioxy)benzylidene>methyl>-2-(2,5-dihydro-1,1-dioxothienyl)acetamide (82281-23-0)

Guidance literature:

With N,N-diethylaniline; In benzene; Yield given; 1.) -78 deg C, 2 h, 2.) RT, 2 h;

DOI:10.1021/jo00140a008

upstream raw materials:

[2-Benzo[1,3]dioxol-5-yl-eth-(Z)-ylidene]-benzyl-amine

2-(2,5-Dihydro-1,1-dioxothienyl)acetyl chloride

benzylamine

benzo[1,3]dioxol-5-yl-acetaldehyde

Downstream raw materials:

(E)-N-benzyl-N-<<3,4-(methylnenedioxy)benzylidene>methyl>-3(E),5-hexadienamide

N-benzyl-2-oxo-7-<3,4-(methylenedioxy)phenyl>-2,3,3a,6,7,7a,-hexahydroindole

(3aR*,7R*,7aS*)-N-benzyl-2-oxo-7-<3,4-(methylenedioxy)phenyl>-2,3,3a,6,7,7a,-hexahydroindole

(3aR*,4R*,9aS*)-N-benzyl-2-oxo-4-vinyl-2,3,3a,4,9,9a,-hexahydro-6,7-(methylenedioxy)benzindole

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