(2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester

Base Information

• Chemical Name: (2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester
• CAS No.: 862155-30-4
• Molecular Formula: C₇₃H₇₂N₂O₂₁
• Molecular Weight: 1313.38
• Mol file: 862155-30-4.mol

Synonyms:(2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester

Chemical Property of (2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester

There total 1 articles about (2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(2R,3R)-2-(6-Amino-hexanoyloxy)-3-benzoyloxy-succinic acid dibenzyl ester; hydrochloride + (2R,3R)-2-(benzoyloxy)-3-hydroxybutanedioic acid (87172-82-5) → (2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester (862155-30-4)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/chem.200401327

Reference yield: 73.0%

(2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester (862155-30-4) + 4-{2-[(3-bromopropoxy)carbonyl]acetoyloxy}butanoic acid (943297-58-3) → C83H85BrN2O26

Guidance literature:

With dmap; N,N-dicyclohexylurea; benzotriazol-1-ol; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200601044

Reference yield: 65.0%

(2R,3R)-2-Benzoyloxy-3-(6-{(2R,3R)-2-benzoyloxy-3-[5-((1R,2R)-2-benzoyloxy-1,2-bis-benzyloxycarbonyl-ethoxycarbonyl)-pentylcarbamoyl]-3-hydroxy-propionylamino}-hexanoyloxy)-succinic acid dibenzyl ester (862155-30-4) + 1-(5-carboxypentyl)-1,3,5-triazin-2,4,6-trione (887765-91-5) → C31H31O8NHCOCH(O2CC6H5)CH(CONHC31H31O8)O2C(CH2)5C3H2N3O3 (887765-88-0)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1002/chem.200501300

upstream raw materials:

(2R,3R)-2-(benzoyloxy)-3-hydroxybutanedioic acid

Downstream raw materials:

C₃₁H₃₁O₈NHCOCH(O₂CC₆H₅)CH(CONHC₃₁H₃₁O₈)O₂C(CH₂)5C₃H₂N₃O₃