2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

Base Information

Chemical Name:2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile
CAS No.:1431943-64-4
Molecular Formula:C₂₃H₂₁F₂N₃O₃
Molecular Weight:425.435
Hs Code.:

Synonyms:2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

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Chemical Property of 2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

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Technology Process of 2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

There total 10 articles about 2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431944-67-0
fluoro(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde

: 1431944-00-1
2-fluoro-5-[2-(2-oxopiperazin-1-yl)ethyl]benzonitrile

: 1431943-64-4
2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

Guidance literature:: With sodium tris(acetoxy)borohydride; at 20 ℃; for 12h;

Reference yield:

: 64169-34-2
5-bromophthalide

: 1431943-64-4
2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium chloride; tetrabutylammonium acetate; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 90 °C

1.2: 0.17 h / 20 °C / Cooling

2.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

4.1: triethylamine tris(hydrogen fluoride) / 8 h / 110 °C

5.1: sodium periodate / tetrachloromethane; water; tert-butyl alcohol / 1.5 h

6.1: sodium tris(acetoxy)borohydride / 12 h / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; potassium chloride; tetrabutylammonium acetate; palladium diacetate; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine tris(hydrogen fluoride); 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: C₁₃H₁₅ClFN₃O

: 1431943-64-4
2-fluoro-5-(2-{4-[2-fluoro-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}ethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / Reflux; Inert atmosphere

2: sodium tris(acetoxy)borohydride / 12 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; In ethanol;