[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester

Base Information

• Chemical Name: [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester
• CAS No.: 120609-31-6
• Molecular Formula: C₁₆H₂₄NO₆P
• Molecular Weight: 357.343
• Mol file: 120609-31-6.mol

Synonyms:[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester

Chemical Property of [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester

There total 1 articles about [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid methyl ester (96-32-2) + <1(R)-<(benzyloxycarbonyl)amino>-3-methylbutyl>phosphinic acid (120707-56-4) → [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester (120609-31-6)

Guidance literature:

With chloro-trimethyl-silane; triethylamine; Multistep reaction; 1.) THF, r.t., 2.) 2 h;

DOI:10.1021/jm00127a041

Reference yield:

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester (120609-31-6) → 2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester (120609-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂ / 5 percent Pd/C / methanol / 6 h / Ambient temperature

2: 12 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00127a041

Reference yield:

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid methyl ester (120609-31-6) → 2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester (120609-57-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / H₂ / 5 percent Pd/C / methanol / 6 h / Ambient temperature

2: 12 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

3: 100 percent / H₂ / 10 percent Pd/C / methanol; ethyl acetate / 827.4 Torr

4: 47 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00127a041

upstream raw materials:

bromoacetic acid methyl ester

<1(R)-<(benzyloxycarbonyl)amino>-3-methylbutyl>phosphinic acid

Downstream raw materials:

2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester