ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate

Base Information

• Chemical Name: ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate
• CAS No.: 131061-65-9
• Molecular Formula: C₂₀H₂₅N₅O₄
• Molecular Weight: 399.45

Synonyms:ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate

Chemical Property of ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate

There total 4 articles about ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-chloro-butyric acid ethyl ester (3153-36-4) + 8-benzylaminotheophylline sodium salt (131061-64-8) → ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate (131061-65-9)

Guidance literature:

In N,N-dimethyl-formamide; for 10h; Heating;

DOI:10.1007/BF01180116

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) + 8-(benzylamino)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione (57000-13-2) → ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate (131061-65-9)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.ejmech.2018.01.068

Reference yield:

8-bromotheophylline (10381-75-6) → ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate (131061-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methoxy-ethanol / 80 h / Reflux

2: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / acetone / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In 2-methoxy-ethanol; acetone;

DOI:10.1016/j.ejmech.2018.01.068

upstream raw materials:

4-chloro-butyric acid ethyl ester

8-benzylaminotheophylline sodium salt

8-bromotheophylline

Ethyl 4-bromobutyrate

Downstream raw materials:

1,3-dimethyl-10-benzyl-2,4,9-trioxo-1,3,6,7,8,10-hexahydro-1,3-diazepino<2,1-f>-purine

4-(8-benzylaminotheophylline-7-yl)-butanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 131061-65-9 ethyl 4-[8-(benzylamino)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl]butanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send