{(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

Base Information

Chemical Name:{(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol
CAS No.:376647-42-6
Molecular Formula:C₁₈H₂₈O₄P₂
Molecular Weight:370.365
Hs Code.:

Synonyms:{(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

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Chemical Property of {(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

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Technology Process of {(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

There total 4 articles about {(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 376647-41-5
C₄₂H₈₄O₄P₂Si₄

: 376647-42-6
{(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

Guidance literature:: With trifluoroacetic acid; In methanol; at 20 ℃; for 10h;
DOI:10.1021/ja011500a

Reference yield:

: 24211-51-6
(2S,5S)-hexane-1,2,5,6-tetrol

: 376647-42-6
{(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 71 percent / imidazole / dimethylformamide / 2.5 h / 0 °C

2.1: 88 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 1.5 h / -30 °C

3.2: 50 percent / tetrahydrofuran / 16 h / -30 °C

4.1: 84 percent / CF₃CO₂H / methanol / 10 h / 20 °C

With 1H-imidazole; n-butyllithium; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja011500a

Reference yield:

: 131618-28-5
(2S,5S)-1,6-Bis<(tert-butyldimethylsilyl)oxy>-2,5-hexanediol

: 376647-42-6
{(2R,5R)-1-[2-((2R,5R)-2,5-Bis-hydroxymethyl-phospholan-1-yl)-phenyl]-5-hydroxymethyl-phospholan-2-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1.5 h / -30 °C

2.2: 50 percent / tetrahydrofuran / 16 h / -30 °C

3.1: 84 percent / CF₃CO₂H / methanol / 10 h / 20 °C

With n-butyllithium; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja011500a