1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

Base Information

Chemical Name:1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione
CAS No.:1334297-74-3
Molecular Formula:C₂₄H₂₇ClN₂O₇
Molecular Weight:490.941
Hs Code.:

Synonyms:1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

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Chemical Property of 1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

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Technology Process of 1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

There total 20 articles about 1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1356964-50-5
3-ethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazolidine-2,4-dione

: (2S,3R,4S,5R)-2-(3-(bromomethyl)-4-chlorophenyl)-3,4,5-tris(methoxymethoxy)-6-((methoxymethoxy)methyl)tetrahydro-2H-pyran

: 1334297-74-3
1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

Guidance literature:: 3-ethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazolidine-2,4-dione; (2S,3R,4S,5R)-2-(3-(bromomethyl)-4-chlorophenyl)-3,4,5-tris(methoxymethoxy)-6-((methoxymethoxy)methyl)tetrahydro-2H-pyran; With sodium carbonate; palladium; In water; N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 20 ℃;

Reference yield:

: 1334297-80-1
C₃₂H₄₃ClN₂O₁₁

: 1334297-74-3
1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃;
DOI:10.1016/j.bmc.2014.04.036

Reference yield:

: 866605-95-0
(5-bromo-2-chlorobenzyloxy)(tert-butyl)diphenylsilane

: 1334297-74-3
1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 2 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / dichloromethane / 24 h / 0 - 20 °C

3.2: 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

5.1: triethylamine; methanesulfonyl chloride / ethyl acetate; toluene / 2 h / 0 °C

5.2: 1 h / 0 - 20 °C

6.1: sodium carbonate / palladium / N,N-dimethyl-formamide; water / 4 h / 80 °C / Inert atmosphere

6.2: 20 °C

With triethylsilane; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; sodium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;