5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

Base Information

Chemical Name:5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate
CAS No.:1427311-65-6
Molecular Formula:C₂₅H₃₅N₄O₁₇P₃S
Molecular Weight:788.557
Hs Code.:

Synonyms:5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

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Chemical Property of 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

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Technology Process of 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

There total 11 articles about 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₄F₃N₄O₁₈P₃S

: 1427311-65-6
5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

Guidance literature:: With ammonium hydroxide; In water; at 20 ℃; for 1h; pH=9.2;

Reference yield:

: 1028383-90-5
N³-tert-butyloxycarbonyl-5-bromomethyl-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyuridine

: 1427311-65-6
5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.75 h / 110 °C / Inert atmosphere

2.1: ammonium fluoride / methanol / 12 h / 50 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 50 °C

4.1: trichlorothiophosphine; triethyl phosphate; 2,6-dimethylpyridine / 1 h / 20 °C / Inert atmosphere

4.2: 0.03 h / 20 °C / Inert atmosphere

4.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

5.1: ammonium hydroxide / water / 1 h / 20 °C / pH 9.2

With 2,6-dimethylpyridine; trichlorothiophosphine; ammonium fluoride; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl phosphate; triethylamine; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 766-85-8
3-methoxy-1-iodobenzene

: 1427311-65-6
5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2’-deoxyuridine-5’-α-thiotriphosphate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium nitrite; acetic acid; nitric acid / 24 h / 20 °C

1.2: 60 °C

2.1: phenylmagnesium chloride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

2.2: 3 h / -30 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: dmap / dichloromethane / 20 °C / Inert atmosphere

4.1: ethanol / Reflux

5.1: potassium carbonate; methanol / 1 h / Reflux

6.1: 0.75 h / 110 °C / Inert atmosphere

7.1: ammonium fluoride / methanol / 12 h / 50 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 50 °C

9.1: trichlorothiophosphine; triethyl phosphate; 2,6-dimethylpyridine / 1 h / 20 °C / Inert atmosphere

9.2: 0.03 h / 20 °C / Inert atmosphere

9.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

10.1: ammonium hydroxide / water / 1 h / 20 °C / pH 9.2

With 2,6-dimethylpyridine; methanol; trichlorothiophosphine; dmap; ammonium fluoride; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl phosphate; phenylmagnesium chloride; nitric acid; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;