N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester

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Chemical Name:N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester
CAS No.:675606-45-8
Molecular Formula:C₃₀H₃₂N₂O₉
Molecular Weight:564.592
Hs Code.:

Synonyms:N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester

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Chemical Property of N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester

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Technology Process of N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester

There total 2 articles about N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 675606-44-7
5R-({5S-[(9H-fluoren-9-ylmethoxycarbonyl-amino)methyl]-2,2-dimethyl-[1,3]dioxolane-4S-ylmethyl}-carbamoyl)-2,2-dimethyl-[1,3]dioxolane-4R-carboxylic acid benzyl ester

: 675606-45-8
N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2004.03.052

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 675606-45-8
N-[4-(9H-fluoren-9ylmethoxycarbonylamino)-2S,3S-dihydroxybutyl]-2R,3R-dihydroxysuccinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / tetrahydrofuran / 0.5 h / cooling

2: 24 percent / bromo-tris(pyrrolidino)phosphonium hexafluorophosphate; N,N'-diisopropylethylamine / dimethylformamide / 17 h / 20 °C

3: 55 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.03.052