4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester
CAS No.:356068-11-6
Molecular Formula:C₂₀H₃₀O₅Si
Molecular Weight:378.541
Hs Code.:

4-benzyloxy-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3,4-dihydro-2<i>H</i>-pyran-2-carboxylic acid methyl ester

Synonyms:4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

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Chemical Property of 4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

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Technology Process of 4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

There total 12 articles about 4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1000-50-6
butyldimethylsilyl chloride

: 356068-09-2
(2R,3S,4R)-4-Benzyloxy-3-hydroxy-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

: 356068-11-6
4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

Guidance literature:: With 1H-imidazole; In dichloromethane;
DOI:10.1016/S0040-4039(01)00607-4

Reference yield:

: 57690-62-7
methyl 3,4-di-O-acetyl-1,2-dideoxy-D-arabino-hex-1-enopyranuronate

: 356068-11-6
4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / NaOMe / methanol / -20 °C

2.1: Bu₂SnO / benzene / 5 h / Heating

2.2: 27 percent / Bu₄NI / benzene / 8 h / Heating

3.1: 80 percent / NaOMe / methanol / 25 °C

4.1: 85 percent / imidazole / CH₂Cl₂

With 1H-imidazole; sodium methylate; di(n-butyl)tin oxide; In methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)00607-4

Reference yield:

: 65877-63-6,97590-76-6,99396-09-5,5531-09-9
3-O-benzyl-D-glucopyranose

: 356068-11-6
4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine / 80 °C

2: pyridine

3: CrO₃; 3M H₂SO₄ / acetone

4: CH₂Cl₂; methanol

5: 76 percent / hydrazine acetate / dimethylformamide

6: 71 percent / P(OPh)3; Br₂ / pyridine; CH₂Cl₂

7: 90 percent / Zn; vitamin B₁₂; NH₄Cl / methanol

8: 90 percent / NaOMe / methanol / -20 °C

9: 80 percent / NaOMe / methanol / 25 °C

10: 85 percent / imidazole / CH₂Cl₂

With 1H-imidazole; chromium(VI) oxide; triphenyl phosphite; cyanocobalamin; sulfuric acid; bromine; sodium methylate; hydrazinium monoacetate; ammonium chloride; zinc; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(01)00607-4