N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

Base Information

Chemical Name:N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide
CAS No.:1428581-01-4
Molecular Formula:C₂₈H₃₀N₆O₃
Molecular Weight:498.585
Hs Code.:

Synonyms:N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

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Chemical Property of N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

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Technology Process of N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

There total 4 articles about N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428581-97-8
N-((1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

: 1100095-25-7,1238377-35-9
3-(1H-pyrazol-5-yl)phenylboronic acid

: 1428581-01-4
N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1123241-94-0
tert-butyl (1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methylcarbamate

: 1428581-01-4
N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

2.2: 4 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 3.1: |Suzuki-Miyaura Coupling;

Reference yield:

: 1428581-96-7
(1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methanamine 2,2,2-trifluoroacetate

: 1428581-01-4
N-((1-(2-(3-(1H-pyrazol-5-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; 2.1: |Suzuki-Miyaura Coupling;