methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

Base Information

Chemical Name:methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate
CAS No.:1352083-28-3
Molecular Formula:C₂₃H₂₆N₄O₃
Molecular Weight:406.484
Hs Code.:

Synonyms:methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

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Chemical Property of methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

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Technology Process of methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

There total 1 articles about methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1352083-27-2
3-cyclohexyl-2-(pyridin-2-yl)-2H-indazole-6-carboxylic acid

: 14316-06-4
D-alanine methyl ester hydrochloride

: 1352083-28-3
methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 17h;

Reference yield: 90.0%

: 1352083-28-3
methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

: 1352083-30-7
N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alanine

Guidance literature:: methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate; With water; potassium carbonate; In ethanol; at 70 ℃; for 1h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 1352083-28-3
methyl N-{[3-cyclohexyl-2-(pyridin-2-yl)-2H-indazol-6-yl]carbonyl}-D-alaninate

: 1352085-35-8
3-cyclohexyl-N-[(2R)-1-({4-[2-(methylamino)pyrimidin-5-yl]phenyl}amino)-1-oxopropan-2-yl]-2-(pyridin-2-yl)-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; water / ethanol / 1 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h

3: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 150 °C / Microwave irradiation

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;