dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

Base Information

Chemical Name:dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate
CAS No.:357400-61-4
Molecular Formula:C₂₂H₂₆N₆O₇
Molecular Weight:486.484
Hs Code.:

Synonyms:dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

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Chemical Property of dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

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Technology Process of dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

There total 5 articles about dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 357400-64-7
4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoic acid

: 357400-61-4
dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

Guidance literature:: 4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

With diethyl cyanophosphonate; In N,N-dimethyl-formamide; at 20 ℃;

L-glutamic dimethyl ester hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Further stages.;
DOI:10.1021/jm990411u

Reference yield:

: 213256-73-6
methyl p-[N-(2-methoxycarbonylallyl)amino]benzoate

: 357400-61-4
dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 41 percent / NaOMe / methanol / 35 °C

2.1: 56 percent / methanol / Heating

3.1: 100 percent / aq. NaOH / 20 °C

4.1: Et₃N / dimethylformamide / 20 °C

4.2: diethyl cyanophosphonate / dimethylformamide / 20 °C

4.3: 65 percent / Et₃N / dimethylformamide / 20 °C

With sodium hydroxide; sodium methylate; triethylamine; In methanol; N,N-dimethyl-formamide; 1.1: Michael addition;
DOI:10.1021/jm990411u

Reference yield:

: 271253-85-1
methyl 4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoate

: 357400-61-4
dimethyl N-{4-[N-(2-amino-4,7-dioxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / aq. NaOH / 20 °C

2.1: Et₃N / dimethylformamide / 20 °C

2.2: diethyl cyanophosphonate / dimethylformamide / 20 °C

2.3: 65 percent / Et₃N / dimethylformamide / 20 °C

With sodium hydroxide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm990411u