N^α-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester

Base Information

• Chemical Name: N^α-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester
• CAS No.: 118235-08-8
• Molecular Formula: C₃₅H₄₂N₂O₆
• Molecular Weight: 586.728
• Mol file: 118235-08-8.mol

Synonyms:N^α-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester

Chemical Property of N^α-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N^α-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester

There total 3 articles about N^α-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

H-Leu-OBut*AcOH (38024-17-8) + C30H31NO7 → Nα-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester (118235-08-8)

Guidance literature:

With N-methylomorpholina; In tetrahydrofuran; at -20 ℃; for 2h; Yield given;

DOI:10.1071/CH9901623

Reference yield:

O-benzyl-N-Fmoc-L-serine (122889-11-6,83792-48-7) + L-leucine tert-butyl ester hydrochloride (2748-02-9,13081-32-8) → Nα-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester (118235-08-8)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; at -20 ℃; for 2h;

DOI:10.1016/S0040-4039(00)86062-1

Reference yield:

O-benzyl-N-Fmoc-L-serine (122889-11-6,83792-48-7) → Nα-(fluorenylmethoxycarbonyl)-O-(benzyl)serylleucine t-butyl ester (118235-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.05 h / -20 °C

2: N-methylomorpholina / tetrahydrofuran / 2 h / -20 °C

With 4-methyl-morpholine; N-methylomorpholina; In tetrahydrofuran;

DOI:10.1071/CH9901623

upstream raw materials:

O-benzyl-N-Fmoc-L-serine

L-leucine tert-butyl ester hydrochloride

H-Leu-OBu^t*AcOH

Downstream raw materials:

H-Ser(Bzl)-Leu-OBu^t

N^α-(t-butoxycarbonyl)-O-(t-butyl)glutamyl-O-(benzyl)serylleucine t-butyl ester

N^α-(t-butoxycarbonyl)-O-(t-butyl)glutamyl-O-(dibenzylphosphono)serylleucine t-butyl ester