Technology Process of (2-HYDROXYMETHYL-4,5-DIIODO-PHENYL)-METHANOL
There total 4 articles about (2-HYDROXYMETHYL-4,5-DIIODO-PHENYL)-METHANOL which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,5-diiodobenzene-1,2-dicarboxylic acid;
With
borane-THF;
In
tetrahydrofuran;
at 0 - 66 ℃;
for 42h;
Inert atmosphere;
With
potassium carbonate;
In
tetrahydrofuran; water;
at 50 ℃;
for 12h;
Inert atmosphere;
DOI:10.1016/j.tet.2016.06.064
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodine; fuming sulfuric acid / 40 h / 85 °C
2.1: potassium hydroxide / water / 20 h / 100 °C
3.1: borane-THF / tetrahydrofuran / 42 h / 0 - 66 °C / Inert atmosphere
3.2: 12 h / 50 °C / Inert atmosphere
With
borane-THF; fuming sulfuric acid; iodine; potassium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1016/j.tet.2016.06.064
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydroxide / water / 20 h / 100 °C
2.1: borane-THF / tetrahydrofuran / 42 h / 0 - 66 °C / Inert atmosphere
2.2: 12 h / 50 °C / Inert atmosphere
With
borane-THF; potassium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1016/j.tet.2016.06.064
