7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide

Base Information

• Chemical Name: 7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide
• CAS No.: 186550-89-0
• Molecular Formula: C₂₄H₂₃N₃O₃S
• Molecular Weight: 433.531

Synonyms:7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide

Chemical Property of 7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide

Chemical Property:

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Technology Process of 7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide

There total 2 articles about 7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester (186550-17-4) → 7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide (186550-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 7.3 g / HCl / ethyl acetate / 4 h / 20 °C

2: Et₃N / CH₂Cl₂ / 2 h

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate; 1: acidolysis / 2: Condensation;

DOI:10.1021/jm990040h

Reference yield:

7-ethyl-naphthalene-2-sulfonyl chloride + 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride → 7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide (186550-89-0)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

DOI:10.1021/jm990040h

Reference yield:

7-Ethyl-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide (186550-89-0) → 3-[(S)-3-(7-Ethyl-naphthalene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzimidoyl chloride

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 6h;

DOI:10.1021/jm990040h

upstream raw materials:

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester

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