(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

Base Information

Chemical Name:(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione
CAS No.:1335286-93-5
Molecular Formula:C₂₈H₃₉NO₉
Molecular Weight:533.619
Hs Code.:

(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

Synonyms:(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

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Chemical Property of (3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

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Technology Process of (3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

There total 14 articles about (3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1335286-92-4
(S)-2-[(1S,2R)-2-hydroxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-(N-acryloyl-N-phenethylamino)-4-(2-methoxyethoxy)methoxy-2-hexenoate

: 1335286-93-5
(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: C₄₃H₅₉NO₈Si

: 1335286-93-5
(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: 1335286-91-3
(S)-2-[(1S,2R)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyloxycarbonyl]-1-methylethyl (2E,4R,5S)-5-(N-acryloyl-N-phenethylamino)-4-(2-methoxyethoxy)methoxy-2-hexenoate

: 1335286-93-5
(3S,6E,8R,9S,12E,14R,15S)-14-hydroxy-8-(2-methoxyethoxy)methoxy-3,9,15-trimethyl-10-phenethyl-10-aza-4,16-dioxa-6,12-cyclohexadecadiene-1,5,11-trione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C / Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.08.014