4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

Base Information

Chemical Name:4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid
CAS No.:1201818-32-7
Molecular Formula:C₂₃H₁₉Cl₂F₃N₂O₄
Molecular Weight:515.316
Hs Code.:

Synonyms:4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

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Chemical Property of 4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

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Technology Process of 4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

There total 13 articles about 4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1091599-69-7
tert-butyl 4-{2-[6-(bromomethyl)-3,5-dichloro-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 935456-49-8
N-methyl-3-(trifluoromethoxy)aniline

: 1201818-32-7
4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 0.166667h; Irradiation with microwave;

Reference yield:

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 1201818-32-7
4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / water / 0.25 h / 20 °C

1.2: 24 h / 80 °C

1.3: 0.5 h

2.1: sulfuric acid / 4 h / Heating; Reflux

3.1: pyridine / 3 h / 5 °C

4.1: hydrogen; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethyl acetate; water

5.1: N-chloro-succinimide; acetic acid / water / 20 - 70 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 70 °C

7.1: dmap / tetrahydrofuran / 60 °C

8.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

9.1: 1-methyl-pyrrolidin-2-one / 0.17 h / 140 °C / Irradiation with microwave

With pyridine; dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; water; ethyl acetate;

Reference yield:

: 60531-36-4
4-(2-amino-ethyl)-benzoic acid hydrochloride

: 1201818-32-7
4-{2-[3,5-dichloro-6-({methyl[3-(trifluoromethoxy)phenyl]amino}methyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / water / 0.25 h / 20 °C

1.2: 24 h / 80 °C

1.3: 0.5 h

2.1: sulfuric acid / 4 h / Heating; Reflux

3.1: pyridine / 3 h / 5 °C

4.1: hydrogen; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethyl acetate; water

5.1: N-chloro-succinimide; acetic acid / water / 20 - 70 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 70 °C

7.1: dmap / tetrahydrofuran / 60 °C

8.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

9.1: 1-methyl-pyrrolidin-2-one / 0.17 h / 140 °C / Irradiation with microwave

With pyridine; dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; water; ethyl acetate;