2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester

Base Information

• Chemical Name: 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester
• CAS No.: 856571-30-7
• Molecular Formula: C₂₈H₂₇N₃O₅
• Molecular Weight: 485.539
• Mol file: 856571-30-7.mol

Synonyms:2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester

Chemical Property of 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester

There total 5 articles about 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(2-aminobenzoylamino)-3-(4-methoxyphenyl)propionic acid ethyl ester (856571-11-4) + Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester (856571-30-7)

Guidance literature:

Indole-2-carboxylic acid; With phosphorus pentachloride; acetyl chloride; at 20 ℃; for 3h;

2-(2-aminobenzoylamino)-3-(4-methoxyphenyl)propionic acid ethyl ester; With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

isatoic anhydride (118-48-9) → 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester (856571-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 27 percent / Et₃N / ethyl acetate / 4 h / Heating

2.1: AcCl; PCl₅ / 3 h / 20 °C

2.2: 79 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With phosphorus pentachloride; triethylamine; acetyl chloride; In ethyl acetate;

DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

2-acetylamino-2-(4-methoxybenzyl)malonic acid diethyl ester (53612-87-6) → 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-(4-methoxyphenyl)propionic acid ethyl ester (856571-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 75 percent / HCl / H₂O; dioxane / Heating

2.1: 91 percent / HCl / 0 °C

3.1: 27 percent / Et₃N / ethyl acetate / 4 h / Heating

4.1: AcCl; PCl₅ / 3 h / 20 °C

4.2: 79 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; phosphorus pentachloride; triethylamine; acetyl chloride; In 1,4-dioxane; water; ethyl acetate;

DOI:10.1016/j.ejmech.2005.01.002

upstream raw materials:

2-(2-aminobenzoylamino)-3-(4-methoxyphenyl)propionic acid ethyl ester

Indole-2-carboxylic acid

isatoic anhydride

2-acetylamino-2-(4-methoxybenzyl)malonic acid diethyl ester