Remiprostol

Base Information Edit

Chemical Name:Remiprostol
CAS No.:110845-89-1
Molecular Formula:C₂₅H₃₆O₅
Molecular Weight:416.558
Hs Code.:
UNII:YCT6Z40PQR
DSSTox Substance ID:DTXSID00891410
Wikidata:Q27294462
NCI Thesaurus Code:C152188
ChEMBL ID:CHEMBL2106965
Mol file:110845-89-1.mol

Synonyms:REMIPROSTOL;110845-89-1;UNII-YCT6Z40PQR;Remiprostol [USAN:INN];YCT6Z40PQR;SC-48834;4-Heptenoic acid, 7-(2-(6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadienyl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester;methyl (Z)-7-[(1R,2R,3R)-2-[(1E,5E)-6-(cyclopenten-1-yl)-4-hydroxy-4-methylhexa-1,5-dienyl]-3-hydroxy-5-oxocyclopentyl]hept-4-enoate;REMIPROSTOL [INN];Remiprostol (USAN/INN);REMIPROSTOL [USAN];REMIPROSTOL [WHO-DD];SCHEMBL563629;CHEMBL2106965;DTXSID00891410;(+-)-Methyl (Z)-7-((1R,2R,3R)-2-((1E,5E)-(4RS)-6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadienyl)-3-hydroxy-5-oxocyclopentyl)-4-heptenoate;D05715;Q27294462;(+/-)-METHYL (Z)-7-((1R,2R,3R)-2-((1E,5E)-(4RS)-6-(1-CYCLOPENTEN-1-YL)-4-HYDROXY-4-METHYL-1,5-HEXADIENYL)-3-HYDROXY-5-OXOCYCLOPENTYL)-4-HEPTENOATE

Suppliers and Price of Remiprostol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
REMIPROSTOL 95.00%
5MG
$ 497.68

Total 1 raw suppliers

Chemical Property of Remiprostol Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:552.2°Cat760mmHg
Flash Point:179.2°C
PSA：83.83000
Density:1.179g/cm³
LogP:4.20590
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:416.25627424
Heavy Atom Count:30
Complexity:702

Purity/Quality:

98%min ^*data from raw suppliers

REMIPROSTOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC=CC1C(CC(=O)C1CCC=CCCC(=O)OC)O)(C=CC2=CCCC2)O
Isomeric SMILES:CC(C/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CC/C=C\CCC(=O)OC)O)(/C=C/C2=CCCC2)O
Uses Anti-ulcerative.

Technology Process of Remiprostol

There total 3 articles about Remiprostol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110845-89-1,110902-56-2,110903-34-9,137255-19-7,146611-10-1
(+/-)-methyl 7-<2β-<6-(1-cyclopenten-1-yl)-4(R)-hydroxy-4-methyl-1(E),5(E)-hexadienyl>-3α-hydroxy-5-oxo-1α-cyclopentyl>-4(Z)-heptenoate

: 130146-47-3,130271-99-7,141318-60-7
(+/-)-methyl 7-<3α-hydroxy-2β-<6-(2-hydroxy-(E)-cyclopentylidene)-4-methyl-1(E),4(E)-hexadienyl>-5-oxo-1α-cyclopentyl>-4(Z)-heptenoate

: 130146-48-4,130195-52-7
(+/-)-methyl 7-<2β-<6-(1-cyclopenten-1-yl)-4-methyl-1(E),3(Z),5(E)-hexatrienyl>-3α-hydroxy-5-oxo-1α-cyclopentyl>-4(Z)-heptenoate

: 130146-48-4,130195-52-7
(+/-)-methyl 7-<2β-<6-(1-cyclopenten-1-yl)-4-methyl-1(E),3(E),5(E)-hexatrienyl>-3α-hydroxy-5-oxo-1α-cyclopentyl>-4(Z)-heptenoate

: 110845-89-1,110902-56-2,110903-34-9,137255-19-7,146611-10-1
(+/-)-methyl 7-<2β-<6-(1-cyclopenten-1-yl)-4(S)-hydroxy-4-methyl-1(E),5(E)-hexadienyl>-3α-hydroxy-5-oxo-1α-cyclopentyl>-4(Z)-heptenoate

Guidance literature:: With acetic acid; In tetrahydrofuran; water; for 2h; Yields of byproduct given; Ambient temperature;
DOI:10.1021/jm00172a017