1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde

Base Information

• Chemical Name: 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
• CAS No.: 122223-70-5
• Molecular Formula: C₁₅H₁₆FNO
• Molecular Weight: 245.297
• Mol file: 122223-70-5.mol

Synonyms:1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde

Chemical Property of 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde

There total 4 articles about 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-isopropyl-2-methyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole (122223-69-2) → 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde (122223-70-5)

Guidance literature:

With manganese(IV) oxide; triethylamine; In diethyl ether; for 48h; Ambient temperature;

DOI:10.1021/jm00163a011

Reference yield:

4-fluoro-β-nitrostyrene (5153-69-5,706-08-1) → 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde (122223-70-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 22.0 g / sodium methanolate / methanol / 2.25 h / 0 °C

2: 7.3 g / methanol / 1.) 40 deg C, 2 h, 2.) 50 deg C, 5 h

3: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

4: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium methylate; triethylamine; In methanol; diethyl ether;

DOI:10.1021/jm00163a011

Reference yield:

1-isopropyl-2-methyl-3-(methoxycarbonyl)-4-(4-fluorophenyl)-1H-pyrrole (122223-68-1) → 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde (122223-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

2: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In diethyl ether;

DOI:10.1021/jm00163a011

upstream raw materials:

1-isopropyl-2-methyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

4-fluoro-β-nitrostyrene

1-isopropyl-2-methyl-3-(methoxycarbonyl)-4-(4-fluorophenyl)-1H-pyrrole

N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

Downstream raw materials:

3-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal

methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

methyl 3(RS),5(RS)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate