2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate

Base Information

• Chemical Name: 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate
• CAS No.: 136453-58-2
• Molecular Formula: C₂₇H₃₂ClNO₂Si₂
• Molecular Weight: 494.181
• Mol file: 136453-58-2.mol

Synonyms:2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate

Chemical Property of 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate

There total 5 articles about 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

p-chlorphenylisocyanate (104-12-1) + 2,7-bis(trimethylsilyl)fluorene-9-methanol (136453-41-3) → 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate (136453-58-2)

Guidance literature:

In benzene; at 80 ℃; for 4h;

DOI:10.1021/jo001150v

Reference yield:

9,9'-bis(trimethylsilyl)fluorene (7351-45-3) → 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate (136453-58-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 74.4 percent / N-bromosuccinimide; 48percent HBr / acetic acid / 6 h

2: 70.9 percent / Na / toluene

3: 93.8 percent / KOH / aq. ethanol / 2 h / Heating

4: 50.16 percent / n-BuLi / diethyl ether / 0.5 h / 20 °C

5: 86.3 percent / benzene / 4 h / 80 °C

With potassium hydroxide; N-Bromosuccinimide; n-butyllithium; sodium; In diethyl ether; ethanol; acetic acid; toluene; benzene;

DOI:10.1021/jo001150v

Reference yield:

2,7-bis(trimethylsilyl)fluorene (136453-57-1) → 2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate (136453-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 50.16 percent / n-BuLi / diethyl ether / 0.5 h / 20 °C

2: 86.3 percent / benzene / 4 h / 80 °C

With n-butyllithium; In diethyl ether; benzene;

DOI:10.1021/jo001150v

upstream raw materials:

p-chlorphenylisocyanate

2,7-bis(trimethylsilyl)fluorene-9-methanol

9,9'-bis(trimethylsilyl)fluorene

2,7-bis(trimethylsilyl)fluorene

Downstream raw materials:

9-Fluorenylmethyl N-p-chlorphenyl carbamate