[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine

Base Information

• Chemical Name: [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine
• CAS No.: 1240608-96-1
• Molecular Formula: C₂₄H₂₁FN₆O
• Molecular Weight: 428.469
• Mol file: 1240608-96-1.mol

Synonyms:[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine

Chemical Property of [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine

There total 7 articles about [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole (1239719-55-1) + 4-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-amine (1381869-18-6) → [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine (1240608-96-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In tert-butyl alcohol; at 110 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jm201710f

Reference yield:

tert-butyl (5-iodo-4-methoxypyridin-2-yl)carbamate (944935-37-9) → [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine (1240608-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; 1,10-Phenanthroline; potassium carbonate / N,N-dimethyl-formamide / 144 h / 120 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 1,10-Phenanthroline; potassium carbonate; caesium carbonate; XPhos; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/jm201710f

Reference yield:

2?bromo?6?fluoronitrobenzene (886762-70-5) → [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine (1240608-96-1)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 0 - 20 °C

2: iron / acetic acid / 1 h / 60 °C

3: triethylamine / dichloromethane / 15 h / 20 °C

4: hydrogenchloride / water; acetic acid / 2 h / 100 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; caesium carbonate; triethylamine; XPhos; In ethanol; dichloromethane; water; acetic acid; tert-butyl alcohol;

DOI:10.1021/jm201710f

upstream raw materials:

4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole

4-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-amine

tert-butyl (5-iodo-4-methoxypyridin-2-yl)carbamate

2?bromo?6?fluoronitrobenzene