Vitamin D₃ tosylate

Base Information

• Chemical Name: Vitamin D₃ tosylate
• CAS No.: 57733-78-5
• Molecular Formula: C₃₄H₅₀O₃S
• Molecular Weight: 538.835
• Mol file: 57733-78-5.mol

Synonyms:Vitamin D₃ tosylate

Chemical Property of Vitamin D₃ tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Vitamin D₃ tosylate

There total 2 articles about Vitamin D₃ tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

vitamin D3 (67-97-0) + p-toluenesulfonyl chloride (98-59-9) → vitamin D3 tosylate (57733-78-5)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 4 - 20 ℃; for 6.5h; Inert atmosphere; Darkness;

DOI:10.1055/s-0033-1339867

Reference yield:

Vitamin D3 (67-97-0) + p-toluenesulfonyl chloride (98-59-9) → Vitamin D3 tosylate (57733-78-5)

Guidance literature:

In pyridine; at 5 ℃; for 24h;

DOI:10.1021/jo01304a022

Reference yield:

vitamin D3 tosylate (57733-78-5) → C34H49BrO3S

Guidance literature:

With N-Bromosuccinimide; In dimethyl sulfoxide; for 4h; Cooling with ice; Irradiation;

upstream raw materials:

Vitamin D₃

p-toluenesulfonyl chloride

vitamin D₃

Downstream raw materials:

1α-Hydroxyvitamin D₃

5,6-trans-1α-Hydroxyvitamin D₃

5,6-cis-1α-Acetoxyvitamin D₃

5,6-trans-1α-Acetoxyvitamin D₃

Refernces

• 1、 -. "Vitamin D3 compound and preparation method thereof". Paragraph 0027; 0031-0033; 0046; 0050-0052; 0065; 0069-0071. . Retrieved 2019/03/28.
• 2、 Ding, Junyuan,Guo, Xianghai,Zeng, Zhouliangzi,Liu, Ningzhi. "A modified synthesis of the antiosteoporosis drug alfacalcidol via a key photochemical transformation of 1α-5,6-Trans-Vitamin D3". . p. 2606 - 2608. Retrieved 2013/12/04.