3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester
• CAS No.: 929294-12-2
• Molecular Formula: C₂₄H₂₁Cl₂N₃O₂
• Molecular Weight: 454.356

Synonyms:3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester

Chemical Property of 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester

There total 3 articles about 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-amine (907190-89-0) + Ethyl 3-bromopropionate (539-74-2) → 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester (929294-12-2)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 200 ℃; microwave irradiation;

DOI:10.1016/j.bmcl.2006.10.060

Reference yield:

3-(3,5-dichlorophenyl)-3-oxopropanenitrile (69316-09-2) → 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester (929294-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 130 °C / microwave irradiation

2: K₂CO₃; NaI / dimethylformamide / 200 °C / microwave irradiation

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2006.10.060

Reference yield:

2-hydrazinonaphthalene (2243-57-4) → 3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionic acid ethyl ester (929294-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 130 °C / microwave irradiation

2: K₂CO₃; NaI / dimethylformamide / 200 °C / microwave irradiation

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2006.10.060

upstream raw materials:

3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-amine

Ethyl 3-bromopropionate

3-(3,5-dichlorophenyl)-3-oxopropanenitrile

2-hydrazinonaphthalene

Downstream raw materials:

N-[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]-β-alanine

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