(7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

Base Information

Chemical Name:(7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane
CAS No.:915315-59-2
Molecular Formula:C₄₆H₆₂O₄Si₂
Molecular Weight:735.167
Hs Code.:

Synonyms:(7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

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Chemical Property of (7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

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Technology Process of (7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

There total 8 articles about (7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915315-67-2
2-[(7S,8R)-8-(2-Hydroxy-ethyl)-7,8-dimethyl-1,4-dioxa-spiro[4.5]dec-7-yl]-ethanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 915315-59-2
(7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/ol061962z

Reference yield:

: 915315-58-1
(4'aR,8'aS)-dimethyl-1',3',4',5',8',8'a-hexahydro-spiro[[1,3]dioxolane-2,2'-naphthalene]

: 915315-59-2
(7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone gas / CH₂Cl₂; methanol / 0.58 h / -78 °C

1.2: 15.0 g / sodium borohydride / CH₂Cl₂; methanol / 30 h / -15 °C

2.1: 31.0 g / 4-dimethylaminopyridine / dimethylformamide; various solvent(s) / 24 h / 20 °C

With dmap; ozone; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol061962z

Reference yield:

: 915315-57-0
(8'aS)-methyl-1',3',4',5',8',8'a-hexahydro-spiro[[1,3]dioxolane-2,2'-naphthalene]-(4'aS)-carbonitrile

: 915315-59-2
(7s,8R)-bis-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-7,8-dimethyl-1,4-dioxa-spiro[4,5]decane

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminum hydride / toluene / 2 h

2.1: hydrazine hydrate; hydrazine dihydrochloride / triethylene glycol / 1 h / 130 °C

3.1: 8.55 g / KOH / 220 °C

4.1: ozone gas / CH₂Cl₂; methanol / 0.58 h / -78 °C

4.2: 15.0 g / sodium borohydride / CH₂Cl₂; methanol / 30 h / -15 °C

5.1: 31.0 g / 4-dimethylaminopyridine / dimethylformamide; various solvent(s) / 24 h / 20 °C

With dmap; potassium hydroxide; hydrazine dihydrochloride; diisobutylaluminium hydride; ozone; hydrazine hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol;
DOI:10.1021/ol061962z