(S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

Base Information

Chemical Name:(S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate
CAS No.:1321963-56-7
Molecular Formula:C₁₆H₁₅F₃N₄O₆
Molecular Weight:416.314
Hs Code.:

Synonyms:(S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

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Technology Process of (S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

There total 5 articles about (S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 187235-66-1
(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-6-amine

: 1321963-28-3
methyl 5-formyl-2-(trifluoromethoxy)benzoate

: 1321963-56-7
(S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

Guidance literature:: (S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-6-amine; methyl 5-formyl-2-(trifluoromethoxy)benzoate; With acetic acid; In N,N-dimethyl-formamide; at 20 ℃;

With sodium cyanoborohydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm1010644

Reference yield:

: C₁₀H₉F₃O₄

: 1321963-56-7
(S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 0.5 h

2: acetic acid / N,N-dimethyl-formamide / 20 °C

With acetic acid; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1010644

Reference yield:

: C₁₆H₂₃F₃O₄Si

: 1321963-56-7
(S)-methyl 5-((2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]-oxazin-6-ylamino)methyl)-2-(trifluoromethoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

2: pyridinium chlorochromate / dichloromethane / 0.5 h

3: acetic acid / N,N-dimethyl-formamide / 20 °C

With tetrabutyl ammonium fluoride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1010644