ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Base Information

Chemical Name:ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine
CAS No.:253449-31-9
Molecular Formula:C₃₀H₄₂N₂O₃S
Molecular Weight:510.741
Hs Code.:

Synonyms:ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

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Chemical Property of ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Chemical Property:

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Technology Process of ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

There total 4 articles about ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4442-85-7
2-cyclohexylethylamine

: 215919-23-6
ethyl N-<4-formyl-2-(2-methylphenyl)benzoyl>-L-methionine

: 253449-31-9
ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
DOI:10.1021/jm990335v

Reference yield:

: 215919-30-5
methyl 5-(hydroxymethyl)-2'-methyl(1,1'-biphenyl)-2-carboxylate

: 253449-31-9
ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Guidance literature:: Multi-step reaction with 4 steps

1: aq.LiOH / methanol / 3.5 h / Heating

2: EDCI; HOBt; NMM

4: NaBH(OAc)3 / 1,2-dichloro-ethane / 3 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; 1,2-dichloro-ethane; 1: saponification / 2: Condensation / 3: Swern oxidation / 4: reductive amination;
DOI:10.1021/jm990335v

Reference yield:

: 253449-47-7
5-(hydroxymethyl)-2'-methyl(1,1'-biphenyl)-2-carboxylic Acid

: 253449-31-9
ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Guidance literature:: Multi-step reaction with 3 steps

1: EDCI; HOBt; NMM

3: NaBH(OAc)3 / 1,2-dichloro-ethane / 3 h / 20 °C

With 4-methyl-morpholine; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; 1: Condensation / 2: Swern oxidation / 3: reductive amination;
DOI:10.1021/jm990335v