methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Base Information

Chemical Name:methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate
CAS No.:956466-26-5
Molecular Formula:C₂₅H₃₁F₆NO₂
Molecular Weight:491.517
Hs Code.:

Synonyms:methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

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Chemical Property of methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

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Technology Process of methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

There total 6 articles about methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956466-34-5
methyl {(2S,3R)-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

: 917-92-0
3,3-Dimethylbut-1-yne

: 406-87-1
4,4,4-trifluorobutanal

: 956466-26-5
methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Guidance literature:: With gold(III) tribromide; In water; at 70 ℃; for 16h;

Reference yield:

: (+/-)-methyl {(6S*,7R*)-7-[4-(trifluoromethyl)phenyl]-1,4-dithia-8-azaspiro[4.5]dec-6-yl}acetate

: 956466-26-5
methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: nickel / methanol; water / 3 h / Heating / reflux

2: dichloromethane / 16 h / 20 °C

3: Resolution of racemate

4: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

5: gold(III) tribromide / water / 16 h / 70 °C

With gold(III) tribromide; trifluoroacetic acid; nickel; In methanol; dichloromethane; water;

Reference yield:

: (+/-)-benzyl (2R*,3S*)-3-(2-methoxy-2-oxoethyl)-4-oxo-2-[4-(trifluoromethyl)phenyl]-3,4-dihydropyridine-1(2H)-carboxylate

: 956466-26-5
methyl {(2S,3R)-1-[(1S)-4,4-dimethyl-1-(3,3,3-trifluoropropyl)pent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Guidance literature:: Multi-step reaction with 7 steps

1: L-Selectride / tetrahydrofuran / 0.03 h / -78 °C

2: boron trifluoride diethyl etherate / dichloromethane / 48 h / 0 - 20 °C

3: nickel / methanol; water / 3 h / Heating / reflux

4: dichloromethane / 16 h / 20 °C

5: Resolution of racemate

6: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

7: gold(III) tribromide / water / 16 h / 70 °C

With gold(III) tribromide; boron trifluoride diethyl etherate; L-Selectride; trifluoroacetic acid; nickel; In tetrahydrofuran; methanol; dichloromethane; water;