(5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Base Information

Chemical Name:(5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate
CAS No.:1227685-25-7
Molecular Formula:C₁₇H₂₀N₂O₃
Molecular Weight:300.357
Hs Code.:

Synonyms:(5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Suppliers and Price of (5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

There total 8 articles about (5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1227685-24-6
(5R,7S)-benzyl 4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

: 1227685-25-7
(5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo400016m

Reference yield:

: 1227685-20-2
(2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate

: 1227685-25-7
(5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 0.5 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1.5 h / 25 °C / Inert atmosphere

4: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium ethanolate; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane; 2: |Dieckmann Condensation;
DOI:10.1021/jo400016m

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1227685-25-7
(5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: magnesium chloride; lithium hexamethyldisilazane / 1,2-dimethoxyethane / 4 h / -78 - -20 °C / Inert atmosphere

2: 18-crown-6 ether; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C / Inert atmosphere; Cooling with ice

3: zinc; acetic acid / tetrahydrofuran / 20 h / 20 - 50 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

5: sodium ethanolate / ethanol / 0.5 h / 20 °C / Inert atmosphere

6: sodium tetrahydroborate / methanol / 1.5 h / 25 °C / Inert atmosphere

7: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium azide; 18-crown-6 ether; sodium ethanolate; acetic acid; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; magnesium chloride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; 5: |Dieckmann Condensation;
DOI:10.1021/jo400016m