t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

Base Information

Chemical Name:t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate
CAS No.:1187357-94-3
Molecular Formula:C₅₇H₅₉N₁₁O₁₁
Molecular Weight:1074.16
Hs Code.:

t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

Synonyms:t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

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Chemical Property of t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

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Technology Process of t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

There total 2 articles about t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187357-93-2
2-[6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxycarbonyl)guanidino}ethyl]amino-9H-purin-9-yl]acetic acid

: 169396-89-8
tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate

: 1187357-94-3
t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: ethyl 2-[2-[2-{2,3-bis-(benzyloxycarbonyl)-guanidino}ethyl]amino-6-oxo-6,9-dihydro-1H-purin-2-yl]acetate

: 1187357-94-3
t-butyl N-[2-{(9H-fluoren-9-yl)methoxycarbonyl-amino}ethyl]-N-[2-{6-(benzyloxycarbonylamino)-2-[2-{2,3-bis-(benzyloxy-carbonyl)-guanidino}ethyl]amino-9H-purin-9-yl}acetyl]glycinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

1.2: 0 °C / pH 5 - 6

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;