(S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

Base Information

Chemical Name:(S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt
CAS No.:137255-92-6
Molecular Formula:C₁₆H₁₆ClNO₂*ClH
Molecular Weight:326.222
Hs Code.:

Synonyms:(S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

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Chemical Property of (S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

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Technology Process of (S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

There total 4 articles about (S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 137255-88-0
(S)-methyl α-{[(1,1-dimethylethoxy)carbonyl]amino}-4'-chloro(1,1'-biphenyl)-4-propanoate

: 137255-92-6
(S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 3h; Ambient temperature;
DOI:10.1021/jo00027a066

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 137255-92-6
(S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 1) K₂CO₃ / 2) Pd(PPh₃)4 / 1) toluene, 15 min, 2) 3 h, 85-90 deg C

3: 93 percent / HCl / ethyl acetate / 3 h / Ambient temperature

With pyridine; hydrogenchloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; ethyl acetate;
DOI:10.1021/jo00027a066

Reference yield:

: 112766-18-4
methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate

: 137255-92-6
(S)-methyl α-amino-4'-chloro(1,1'-biphenyl)-4-propanoate hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1: 1) K₂CO₃ / 2) Pd(PPh₃)4 / 1) toluene, 15 min, 2) 3 h, 85-90 deg C

2: 93 percent / HCl / ethyl acetate / 3 h / Ambient temperature

With hydrogenchloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethyl acetate;
DOI:10.1021/jo00027a066