Technology Process of 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid
There total 5 articles about 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate;
With
water; sodium hydroxide;
In
methanol;
at 60 ℃;
for 12h;
In
methanol;
Acidic conditions;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 12 h / 80 °C / Sealed
2.1: sodium sulfide; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
4.1: sodium hydroxide; water / methanol / 12 h / 60 °C
4.2: Acidic conditions
With
4-methyl-morpholine; sodium sulfide; water; sodium carbonate; potassium carbonate; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 12 h / 80 °C / Sealed
2.1: sodium sulfide; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
4.1: sodium hydroxide; water / methanol / 12 h / 60 °C
4.2: Acidic conditions
With
4-methyl-morpholine; sodium sulfide; water; sodium carbonate; potassium carbonate; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
