toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester
CAS No.:478855-02-6
Molecular Formula:C₃₁H₂₇NO₆S
Molecular Weight:541.624
Hs Code.:

Synonyms:toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

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Chemical Property of toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

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Technology Process of toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

There total 7 articles about toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 478855-41-3
toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-phenyl ester

: 478855-02-6
toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

Guidance literature:: With air; palladium on activated charcoal; In acetonitrile; at 20 ℃;
DOI:10.1021/jm020831a

Reference yield:

: 621-59-0
isovanillin

: 478855-02-6
toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / K₂CO₃ / ethanol / 5 h / Heating

2: 88 percent / NH₄OAc; AcOH / 4 h / Heating

3: 63 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

4: 5percent aq. NaOH / CH₂Cl₂ / 2 h / 20 °C

5: POCl₃ / CH₂Cl₂ / 3 h / Heating

6: air / Pd/C / acetonitrile / 20 °C

With lithium aluminium tetrahydride; air; ammonium acetate; potassium carbonate; acetic acid; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetonitrile; 4: Schotten-Baumann reaction / 5: Bischler-Napieralski cyclodehydration;
DOI:10.1021/jm020831a

Reference yield:

: 63909-29-5,55507-05-6
3-benzyloxy-4-methoxy-β-nitrostyrene

: 478855-02-6
toluene-4-sulfonic acid 4-(6-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline-1-carbonyl)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

2: 5percent aq. NaOH / CH₂Cl₂ / 2 h / 20 °C

3: POCl₃ / CH₂Cl₂ / 3 h / Heating

4: air / Pd/C / acetonitrile / 20 °C

With lithium aluminium tetrahydride; air; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 2: Schotten-Baumann reaction / 3: Bischler-Napieralski cyclodehydration;
DOI:10.1021/jm020831a