4-Methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile

Base Information

Chemical Name:4-Methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile
CAS No.:124315-52-2
Molecular Formula:C₁₃H₈N₄O
Molecular Weight:236.233
Hs Code.:
European Community (EC) Number:688-616-1

Synonyms:4-METHYL-6-OXO-1-PHENYL-1,6-DIHYDRO-PYRIDAZINE-3,5-DICARBONITRILE;AKOS022659665;124315-52-2;4-Methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:236.06981089
Heavy Atom Count:18
Complexity:534

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=O)N(N=C1C#N)C2=CC=CC=C2)C#N

Technology Process of 4-Methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile

There total 5 articles about 4-Methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 105-56-6
ethyl 2-cyanoacetate

: 176752-00-4
(2E)-3-oxo-2-(2-phenylhydrazinylidene)butanenitrile

: 124315-52-2
4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile

Guidance literature:: With ammonium acetate; acetic acid; for 0.0166667h; Heating; microwave irradiation;
DOI:10.1080/10426500500536457

Reference yield: 80.0%

: 105-56-6
ethyl 2-cyanoacetate

: 28317-57-9
phenylazo acetylacetonitrile

: 124315-52-2
4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile

Guidance literature:: With ammonium acetate; at 160 ℃; for 0.75h; or with AcOH-benzene, 20h, reflux;

Reference yield:

: 28317-57-9
phenylazo acetylacetonitrile

: 124315-52-2
4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / ammonium acetate / 5 h / 120 - 130 °C

2: acetic acid / 2 h / Heating

With ammonium acetate; In acetic acid;