methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

Base Information

Chemical Name:methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate
CAS No.:1444255-08-6
Molecular Formula:C₂₄H₂₆N₂O₃S
Molecular Weight:422.548
Hs Code.:

Synonyms:methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

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Chemical Property of methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

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Technology Process of methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

There total 4 articles about methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1444258-10-9
4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzaldehyde

: 343238-58-4
methyl azetidine-3-carboxylate

: 1444255-08-6
methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: 4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzaldehyde; methyl azetidine-3-carboxylate; With acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; chloroform; at 20 ℃; for 1h;

With 2-picoline borane complex; In methanol; chloroform; at 20 ℃; for 16h;

Reference yield:

: 198904-53-9
4-(thiazol-2-yl)-benzaldehyde

: 1444255-08-6
methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 21 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 5 h / 87 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; acetic acid / methanol; chloroform / 1 h / 20 °C

3.2: 16 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1444258-05-2
4-(5-bromothiazol-2-yl)benzaldehyde

: 1444255-08-6
methyl 1-(4-(5-(4-isopropoxyphenyl)thiazol-2-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 5 h / 87 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; acetic acid / methanol; chloroform / 1 h / 20 °C

2.2: 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; chloroform; water;