6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Base Information

• Chemical Name: 6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine
• CAS No.: 941596-89-0
• Molecular Formula: C₄₀H₄₁BrN₄O₇
• Molecular Weight: 769.692

Synonyms:6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Chemical Property of 6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Chemical Property:

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Technology Process of 6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

There total 2 articles about 6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-chloro-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine (756494-07-2) → 6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine (941596-89-0)

Guidance literature:

With trimethylsilyl bromide; In butanone; at -40 ℃; for 2h;

DOI:10.1021/ja070021u

Reference yield:

2',3',5'-tri-O-(2,4,6-trimethylbenzoyl)inosine (756494-06-1) → 6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine (941596-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; N,N-dimethylaniline / acetonitrile / Heating

2: 80 percent / trimethylsilyl bromide / butan-2-one / 2 h / -40 °C

With trimethylsilyl bromide; N,N-dimethyl-aniline; trichlorophosphate; In acetonitrile; butanone;

DOI:10.1021/ja070021u

Reference yield:

6-bromo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine (941596-89-0) + aniline (62-53-3) → 6-N-phenyl-2',3',5'-tri-O-(2,4,6-trimethylbenzoyl)adenosine

Guidance literature:

With trifluoroacetic acid; In acetonitrile; at 50 ℃; Kinetics;

DOI:10.1021/ja070021u

upstream raw materials:

6-chloro-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

2',3',5'-tri-O-(2,4,6-trimethylbenzoyl)inosine

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