N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

Base Information

Chemical Name:N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide
CAS No.:1447331-45-4
Molecular Formula:C₂₂H₂₁N₃O₄
Molecular Weight:391.426
Hs Code.:

Synonyms:N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

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Chemical Property of N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

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Technology Process of N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

There total 2 articles about N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 620169-61-1
C₁₂H₁₃NO₄

: C₁₀H₁₀N₂O*H⁽¹⁺⁾

: 1447331-45-4
N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

Guidance literature:: C₁₂H₁₃NO₄; With 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

C₁₀H₁₀N₂O*H⁽¹⁺⁾; In 1-methyl-pyrrolidin-2-one; at 20 ℃;
DOI:10.1016/j.tetlet.2013.05.095

Reference yield:

: 39910-98-0
4-morpholinoacetophenone

: 1447331-45-4
N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: selenium(IV) oxide; pyridine

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

2.2: 20 °C

With pyridine; selenium(IV) oxide; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one;
DOI:10.1016/j.tetlet.2013.05.095

Reference yield: 30.0%

: 1447331-45-4
N-(2-(1H-indol-3-yl)-2-oxoethyl)-2-(4-morpholin-4-yl-phenyl)-2-oxoacetamide

: 1447330-92-8
5-(1H-indol-3-yl)-3-(4-morpholino-4-yl-phenyl)pyrazine-2(1H)-one

Guidance literature:: With ammonium acetate; In acetic acid; at 160 ℃; for 0.0666667h; Sealed tube; Microwave irradiation;
DOI:10.1016/j.tetlet.2013.05.095