N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

Base Information

Chemical Name:N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine
CAS No.:1443253-12-0
Molecular Formula:C₂₈H₄₀N₂O₂S
Molecular Weight:468.704
Hs Code.:

Synonyms:N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

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Technology Process of N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

There total 5 articles about N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1443253-24-4
(5-bromo-1-octyl-1H-indol-3-ylmethyl)diethylamine

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1443253-12-0
N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.ejmech.2013.02.007

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1443253-12-0
N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: acetic acid / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.33 h / 100 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; 2.1: |Mannich Aminomethylation / 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.02.007

Reference yield:

: 111-83-1
1-bromo-octane

: 1443253-12-0
N-ethyl-N-{[5-(4-methylsulfonylphenyl)-1-octyl-1H-indol-3-yl]methyl}ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: acetic acid / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.33 h / 100 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; 2.1: |Mannich Aminomethylation / 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.02.007