(S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate
CAS No.:875574-62-2
Molecular Formula:C₂₂H₃₂N₂O₇
Molecular Weight:436.505
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

There total 4 articles about (S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 824943-43-3
(S)-2-benzyloxycarbonylamino-5-(2-[1,3]dioxolanyl)-pentanoic acid methyl ester

: 875574-62-2
(S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Pd/C / ethyl acetate / 4 h / 20 °C

2: 527 mg / BOP; DIPEA / CH₂Cl₂ / 0 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ol052598r

Reference yield:

: 875574-58-6
L-allysine ethylene acetal methyl ester

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 875574-62-2
(S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/ol052598r

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 875574-62-2
(S)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanamido)-5-(1,3-dioxolan-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; NaHCO₃ / H₂O; dioxane / 0 °C

2: 527 mg / BOP; DIPEA / CH₂Cl₂ / 0 °C

With sodium hydroxide; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ol052598r