5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

Base Information

Chemical Name:5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin
CAS No.:226232-81-1
Molecular Formula:C₂₄H₂₁F₆N₃O₃
Molecular Weight:513.439
Hs Code.:

Synonyms:5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

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Chemical Property of 5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

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Technology Process of 5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

There total 7 articles about 5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6160-49-2
1-O-acetyl-3,5-di-O-benzyl-2-deoxy-D-erythro-pentofuranose

: 226232-81-1
5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

Guidance literature:: Multi-step reaction with 3 steps

1: BF₃*Et₂O / acetonitrile / 0.5 h / -40 °C

2: NaOMe / 3 h / 20 °C

3: xylene / 20 h / Heating

With boron trifluoride diethyl etherate; sodium methylate; In acetonitrile; xylene; 1: Substitution / 2: Addition / 3: Cycloaddition;
DOI:10.1515/znb-1999-0420

Reference yield:

: 6160-50-5
3,5-di-O-benzyl-2-deoxy-D-ribofuranose

: 226232-81-1
5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 0.5 h / 20 °C

2: BF₃*Et₂O / acetonitrile / 0.5 h / -40 °C

3: NaOMe / 3 h / 20 °C

4: xylene / 20 h / Heating

With pyridine; boron trifluoride diethyl etherate; sodium methylate; In acetonitrile; xylene; 1: Acetylation / 2: Substitution / 3: Addition / 4: Cycloaddition;
DOI:10.1515/znb-1999-0420

Reference yield:

: 132487-16-2
methyl 3,5-di-O-benzyl-2-deoxy-D-ribofuranoside

: 226232-81-1
5-(3',5'-Di-O-benzyl-2'-desoxy-α-D-ribofuranosyl)-3,6-bis(trifluoromethyl)-1,2,4-triazin

Guidance literature:: Multi-step reaction with 5 steps

1: HCl; H₂O / dioxane / 1 h / Heating

2: pyridine / 0.5 h / 20 °C

3: BF₃*Et₂O / acetonitrile / 0.5 h / -40 °C

4: NaOMe / 3 h / 20 °C

5: xylene / 20 h / Heating

With pyridine; hydrogenchloride; boron trifluoride diethyl etherate; water; sodium methylate; In 1,4-dioxane; acetonitrile; xylene; 1: Hydrolysis / 2: Acetylation / 3: Substitution / 4: Addition / 5: Cycloaddition;
DOI:10.1515/znb-1999-0420