1,4-Dioxane-2-carboxaldehyde

Base Information

Chemical Name:1,4-Dioxane-2-carboxaldehyde
CAS No.:56217-56-2
Molecular Formula:C5H8O3
Molecular Weight:116.11522
Hs Code.:
DSSTox Substance ID:DTXSID40602805
Mol file:56217-56-2.mol

Synonyms:1,4-DIOXANE-2-CARBOXALDEHYDE;1,4-Dioxane-2-carbaldehyde;56217-56-2;MFCD08669508;dioxal;1,4-dioxinan-2-yl-methanone;SCHEMBL1318794;DTXSID40602805;SOYANKPFXHJUCE-UHFFFAOYSA-N;(2R)-1,4-dioxane-2-carbaldehyde;(2S)-1,4-dioxane-2-carbaldehyde;AKOS012322383;SY277014;D78647;EN300-100506;2033064-40-1;934346-74-4

Suppliers and Price of 1,4-Dioxane-2-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,4-DIOXANE-2-CARBOXALDEHYDE 95.00%
5MG
$ 495.80

Total 6 raw suppliers

Chemical Property of 1,4-Dioxane-2-carboxaldehyde

Chemical Property:

Boiling Point:194.1±25.0 °C(Predicted)
PSA：35.53000
Density:1.220±0.06 g/cm3(Predicted)
LogP:-0.39930
XLogP3:-0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:116.047344113
Heavy Atom Count:8
Complexity:81.7

Purity/Quality:

98% ^*data from raw suppliers

1,4-DIOXANE-2-CARBOXALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC(CO1)C=O

Technology Process of 1,4-Dioxane-2-carboxaldehyde

There total 8 articles about 1,4-Dioxane-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.22%

: 406913-93-7,143669-41-4
[(2S)-1,4-dioxan-2-yl]methanol

: 934346-74-4,56217-56-2
(R)-1,4-dioxane-2-carboxaldehyde

Guidance literature:: With 3-isobutyl-1-methylxanthine; In acetonitrile; at 70 ℃; for 4h;

Reference yield: 78.0%

: 29908-11-0,143669-41-4
(+/-)-2-(hydroxymethyl)-1,4-dioxane

: 56217-56-2
1,4-dioxane-2-carbaldehyde

Guidance literature:: With 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1142/S108842462150070X

Reference yield:

: 934346-53-9
(R)-1-(2-chloroethoxy)-3-chloropropan-2-ol

: 934346-74-4,56217-56-2
(R)-1,4-dioxane-2-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NaOH / H₂O / 2 h / 20 °C

2: 36 percent / NaOH / H₂O / 2 h / 90 °C

3: 35 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 5 h / -78 - 20 °C

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; water; 3: Swern oxidation;
DOI:10.1016/j.bmc.2007.01.040