N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

Base Information

Chemical Name:N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide
CAS No.:1375086-48-8
Molecular Formula:C₂₄H₂₃ClN₄O
Molecular Weight:418.926
Hs Code.:

Synonyms:N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

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Chemical Property of N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

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Technology Process of N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

There total 4 articles about N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375086-51-3
3-(4-Chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-amine

: 645-45-4
hydrocinnamic acid chloride

: 1375086-48-8
N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

Guidance literature:: With pyridine; at 20 ℃; for 12h;

Reference yield:

: 116632-41-8
1-chloro-4-iodo-2-methylbenzene

: 1375086-48-8
N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice; Inert atmosphere

1.2: 37 h / Inert atmosphere; Reflux

1.3: pH ~ 3

2.1: hydrazine hydrate / chloroform / 22 h / 70 °C / Inert atmosphere

3.1: acetic acid / 1 h / 100 °C

3.2: 2 h / 20 °C

4.1: pyridine / 12 h / 20 °C

With pyridine; sodium hydride; hydrazine hydrate; In tetrahydrofuran; chloroform; acetic acid; mineral oil;

Reference yield:

: 1375086-49-9
2-(4-Chloro-3-methylphenyl)malononitrile

: 1375086-48-8
N-[3-(4-chloro-3-methylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl]-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / chloroform / 22 h / 70 °C / Inert atmosphere

2.1: acetic acid / 1 h / 100 °C

2.2: 2 h / 20 °C

3.1: pyridine / 12 h / 20 °C

With pyridine; hydrazine hydrate; In chloroform; acetic acid;