2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

Base Information

Chemical Name:2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)
CAS No.:1243141-24-3
Molecular Formula:C₂₂H₂₃FNO₄PS
Molecular Weight:447.467
Hs Code.:

Synonyms:2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

Suppliers and Price of 2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

There total 1 articles about 2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1243141-15-2
(2,4-dimethylphenyl)phosphonic acid monoethyl ester

: 175137-08-3
5-(4-fluorophenyl)-3-aminothiophene-2-carboxylic acid methyl ester

: 1243141-24-3
2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

Guidance literature:: (2,4-dimethylphenyl)phosphonic acid monoethyl ester; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

5-(4-fluorophenyl)-3-aminothiophene-2-carboxylic acid methyl ester; With pyridine; sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h;

Reference yield: 85.0%

: 1243141-24-3
2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

: 121-44-8
triethylamine

: 2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate]-5-(4-fluorophenyl) triethylammonium salt

Guidance literature:: With trimethylsilyl bromide; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

Reference yield: 79.0%

: 1243141-24-3
2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

: 1243139-20-9
2-thiophenecarboxylic acid, 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl)

Guidance literature:: 2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate ethyl ester]-5-(4-fluorophenyl); With water; sodium hydroxide; In methanol; at 20 ℃; for 120h;

With hydrogenchloride; In methanol; water; pH=3;